Selected Publications
W. T. Kimberly, A. J. Sorby-Adams, A. G. Webb, E. X. Wu, R. Beekman, R. Bowry, S. J. Schiff, A. de Havenon, F. X. Shen, G. Sze, P. Schaefer, J. E. Iglesias, M. S. Rosen, and K. N. Sheth, “Brain imaging with portable low-field MRI,” Nat. Rev. Bioeng., pp. 1–14, 2023, doi: 10.1038/s44222-023-00086-w.
A. B. Schmidt, I. Adelabu, C. Nelson, S. Nantogma, V. G. Kiselev, M. Zaitsev, A. Abdurraheem, H. de Maissin, M. S. Rosen, S. Lehmkuhl, S. Appelt, T. Theis, and E. Y. Chekmenev, “13 C Radiofrequency Amplification by Stimulated Emission of Radiation Threshold Sensing of Chemical Reactions,” J Am Chem Soc, May 2023, doi: 10.1021/jacs.3c00776.
M. J. Molway, L. Bales-Shaffer, K. Ranta, J. Ball, E. Sparling, M. Prince, D. Cocking, D. Basler, M. Murphy, B. E. Kidd, A. T. Gafar, J. Porter, K. Albin, M. S. Rosen, E. Y. Chekmenev, W. M. Snow, M. J. Barlow, and B. M. Goodson, “Dramatic Improvement in the ‘Bulk’ Hyperpolarization of 131 Xe via Spin Exchange Optical Pumping Probed Using in Situ Low-Field NMR,” J. Magn. Reson., p. 107521, 2023, doi: 10.1016/j.jmr.2023.107521.
K. MacCulloch, A. Browning, D. G. Bedoya, S. J. McBride, M. B. Abdulmojeed, C. Dedesma, B. M. Goodson, M. S. Rosen, E. Y. Chekmenev, Y.-F. Yen, P. TomHon, and T. Theis, “Facile hyperpolarization chemistry for molecular imaging and metabolic tracking of [1-13C]pyruvate in vivo,” J. Magn. Reson. Open, p. 100129, 2023, doi: 10.1016/j.jmro.2023.100129.
A. de Havenon, N. R. Parasuram, A. L. Crawford, M. H. Mazurek, I. R. Chavva, V. Yadlapalli, J. E. Iglesias, M. S. Rosen, G. J. Falcone, S. Payabvash, G. Sze, R. Sharma, S. J. Schiff, B. Safdar, C. Wira, W. T. Kimberly, and K. N. Sheth, “Identification of White Matter Hyperintensities in Routine Emergency Department Visits Using Portable Bedside Magnetic Resonance Imaging,” J Am Heart Assoc, p. e029242, 2023, doi: 10.1161/jaha.122.029242.
N. R. Parasuram, A. L. Crawford, M. H. Mazurek, I. R. Chavva, R. Beekman, E. J. Gilmore, N. H. Petersen, S. Payabvash, G. Sze, J. E. Iglesias, S. B. Omay, C. Matouk, E. E. Longbrake, A. de Havenon, S. J. Schiff, M. S. Rosen, W. T. Kimberly, and K. N. Sheth, “Future of Neurology & Technology: Neuroimaging Made Accessible Using Low-Field, Portable MRI,” Neurology, vol. 100, no. 22, pp. 1067–1071, 2023, doi: 10.1212/wnl.0000000000207074.
A. E. Campbell‐Washburn, K. E. Keenan, P. Hu, J. P. Mugler, K. S. Nayak, A. G. Webb, J. Obungoloch, K. N. Sheth, J. Hennig, M. S. Rosen, N. Salameh, D. K. Sodickson, J. M. Stein, J. P. Marques, and O. P. Simonetti, “Low‐field MRI: A report on the 2022 ISMRM workshop,” Magn. Reson. Med., 2023, doi: 10.1002/mrm.29743.
N. Sujijantarat, A. B. Koo, I. Jambor, A. Malhotra, M. H. Mazurek, N. Parasuram, V. Yadlapalli, I. R. Chavva, D. Lalwani, J. Zabinska, J. M. Roy, J. P. Antonios, A. A. Elsamadicy, D. Renedo, R. M. Hebert, J. L. Schindler, E. J. Gilmore, L. H. Sansing, A. de Havenon, M. Olexa, S. J. Schiff, J. E. Iglesias, M. Rosen, W. T. Kimberly, N. H. Petersen, K. N. Sheth, and C. C. Matouk, “Low‐Field Portable Magnetic Resonance Imaging for Post‐Thrombectomy Assessment of Ongoing Brain Injury,” Stroke: Vasc. Interv. Neurol., 2023, doi: 10.1161/svin.123.000921.
D. E. J. Waddington, N. Hindley, N. Koonjoo, C. Chiu, T. Reynolds, P. Z. Y. Liu, B. Zhu, D. Bhutto, C. Paganelli, P. J. Keall, and M. S. Rosen, “Real‐time radial reconstruction with domain transform manifold learning for MRI‐guided radiotherapy,” Med Phys, 2023, doi: 10.1002/mp.16224.
S. Raman, G. E. Gold, M. S. Rosen, and B. Sveinsson, “Automatic estimation of knee effusion from limited MRI data,” Sci Rep, vol. 12, no. 1, p. 3155, 2022, doi: 10.1038/s41598-022-07092-9.
K. N. Sheth, M. M. Yuen, M. H. Mazurek, B. A. Cahn, A. M. Prabhat, S. Salehi, J. T. Shah, S. By, E. B. Welch, M. Sofka, L. I. Sacolick, J. A. Kim, S. Payabvash, G. J. Falcone, E. J. Gilmore, D. Y. Hwang, C. Matouk, B. Gordon-Kundu, A. W. RN, N. Petersen, J. Schindler, K. T. Gobeske, L. H. Sansing, G. Sze, M. S. Rosen, W. T. Kimberly, and P. Kundu, “Bedside detection of intracranial midline shift using portable magnetic resonance imaging,” Sci Rep, vol. 12, no. 1, p. 67, 2022, doi: 10.1038/s41598-021-03892-7.
I. R. Chavva, A. L. Crawford, M. H. Mazurek, M. M. Yuen, A. M. Prabhat, S. Payabvash, G. Sze, G. J. Falcone, C. C. Matouk, A. Havenon, J. A. Kim, R. Sharma, S. J. Schiff, M. S. Rosen, J. Kalpathy‐Cramer, J. E. I. Gonzalez, W. T. Kimberly, and K. N. Sheth, “Deep Learning Applications for Acute Stroke Management,” Ann Neurol, 2022, doi: 10.1002/ana.26435.
G. C. Bagnall, S. A. Altobelli, M. S. Conradi, H. T. Fabich, E. Fukushima, N. Koonjoo, D. O. Kuethe, W. L. Rooney, K. F. Stupic, B. Sveinsson, B. Weers, N. Rajan, M. S. Rosen, and C. L. S. Morgan, “Design and demonstration of a low‐field magnetic resonance imaging rhizotron for in‐field imaging of energy sorghum roots,” Plant Phenome J, vol. 5, no. 1, 2022, doi: 10.1002/ppj2.20038.
B. Sveinsson, O. E. Rowe, J. P. Stockmann, D. J. Park, P. J. Lally, M. S. Rosen, R. L. Barry, F. Eichler, B. R. Rosen, and R. Sadjadi, “Feasibility of simultaneous high‐resolution anatomical and quantitative magnetic resonance imaging of sciatic nerves in patients with Charcot–Marie–Tooth type 1A (CMT1A) at 7T,” Muscle Nerve, 2022, doi: 10.1002/mus.27647.
S. Shen, N. Koonjoo, X. Kong, M. S. Rosen, and Z. Zu, “Gradient Coil Design and Optimization for an Ultra-low-field MRI System,” Applied Magnetic Resonance, Apr. 2022, [Online]. Available: https://doi.org/10.1007/s00723-022-01470-2
S. J. DeVience and M. S. Rosen, “Homonuclear J-Coupling Spectroscopy using J-Synchronized Echo Detection,” J Magn Reson, p. 107244, 2022, doi: 10.1016/j.jmr.2022.107244.
M. M. Yuen, A. M. Prabhat, M. H. Mazurek, I. R. Chavva, A. L. Crawford, B. A. Cahn, R. Beekman, J. A. Kim, K. T. Gobeske, N. Petersen, G. J. Falcone, E. J. Gilmore, D. Y. Hwang, A. S. Jasne, H. Amin, R. Sharma, C. C. Matouk, A. Ward, J. Schindler, L. Sansing, A. de Havenon, A. Aydin, C. Wira, G. Sze, M. S. Rosen, W. T. Kimberly, and K. N. Sheth, “Portable, low-field magnetic resonance imaging enables highly accessible and dynamic bedside evaluation of ischemic stroke,” Sci. Adv., Apr. 2022, doi: 10.1126/sciadv.abm3952.
J. E. Iglesias, R. Schleicher, S. Laguna, B. Billot, P. Schaefer, B. McKaig, J. N. Goldstein, K. N. Sheth, M. S. Rosen, and W. T. Kimberly, “Quantitative Brain Morphometry of Portable Low-Field-Strength MRI Using Super-Resolution Machine Learning,” Radiology, p. 220522, Nov. 2022, doi: 10.1148/radiol.220522.
S. Lehmkuhl, S. Fleischer, L. Lohmann, M. S. Rosen, E. Y. Chekmenev, A. Adams, T. Theis, and S. Appelt, “RASER MRI: Magnetic resonance images formed spontaneously exploiting cooperative nonlinear interaction,” Science Advances, Jul. 2022, doi: 10.1126/sciadv.abp8483.
Perlman, O., Zhu, B., Zaiss, M., Rosen, M.S., Farrar, C.T.,. An end‐to‐end AI‐based framework for automated discovery of rapid CEST/MT MRI acquisition protocols and molecular parameter quantification (AutoCEST). Magnet Reson Med. https://doi.org/10.1002/mrm.29173 2022
Sheth, K.N., Yuen, M.M., Mazurek, M.H., Cahn, B.A., Prabhat, A.M., Salehi, S., Shah, J.T., By, S., Welch, E.B., Sofka, M., Sacolick, L.I., Kim, J.A., Payabvash, S., Falcone, G.J., Gilmore, E.J., Hwang, D.Y., Matouk, C., Gordon-Kundu, B., RN, A.W., Petersen, N., Schindler, J., Gobeske, K.T., Sansing, L.H., Sze, G., Rosen, M.S., Kimberly, W.T., Kundu, P., Bedside detection of intracranial midline shift using portable magnetic resonance imaging. Sci Rep 12, 67. https://doi.org/10.1038/s41598-021-03892-7 2022
M. H. Mazurek, B. A. Cahn, M. M. Yuen, A. M. Prabhat, I. R. Chavva, J. T. Shah, A. L. Crawford, E. B. Welch, J. Rothberg, L. Sacolick, M. Poole, C. Wira, C. C. Matouk, A. Ward, N. Timario, A. Leasure, R. Beekman, T. J. Peng, J. Witsch, J. P. Antonios, G. J. Falcone, K. T. Gobeske, N. Petersen, J. Schindler, L. Sansing, E. J. Gilmore, D. Y. Hwang, J. A. Kim, A. Malhotra, G. Sze, M. S. Rosen, W. T. Kimberly, and K. N. Sheth, “Portable, bedside, low-field magnetic resonance imaging for evaluation of intracerebral hemorrhage,” Nat Commun, vol. 12, no. 1, p. 5119, 2021, doi: 10.1038/s41467-021-25441-6.
DeVience, S.J., Greer, M., Mandal, S., Rosen, M.S., Homonuclear J‐Coupling Spectroscopy at Low Magnetic Fields using Spin‐Lock Induced Crossing. Chemphyschem. https://doi.org/10.1002/cphc.202100162 2021
DeVience, S.J., Walsworth, R.L., Rosen, M.S., NMR of 31P Nuclear Spin Singlet States in Organic Diphosphates. J Magn Reson 107101. https://doi.org/10.1016/j.jmr.2021.107101 2021
Arunkumar, N., Bucher, D.B., Turner, M.J., TomHon, P., Glenn, D., Lehmkuhl, S., Lukin, M.D., Park, H., Rosen, M.S., Theis, T., Walsworth, R.L. Micron-Scale NV-NMR Spectroscopy with Signal Amplification by Reversible Exchange. PRX Quantum 2, 010305–6, 2021
Koonjoo, N., Zhu, B., Bagnall, G.C., Bhutto, D., Rosen, M.S.. Boosting the signal-to-noise of low-field MRI with deep learning image reconstruction. Sci Rep 11, 8248, 2021.
Sveinsson, B., Chaudhari, A.S., Zhu, B., Koonjoo, N., Torriani, M., Gold, G.E., Rosen, M.S.. Synthesizing Quantitative T2 Maps in Right Lateral Knee Femoral Condyles from Multi-Contrast Anatomical Data with a Conditional GAN. Radiology Artif Intell e200122, 2021.
Sveinsson, B., Koonjoo, N., Rosen, M.S., 2021. ARmedViewer, an augmented-reality-based fast 3D reslicer for medical image data on mobile devices: A feasibility study. Comput Meth Prog Bio 200, 105836, 2021.
Sheth, K.N., Mazurek, M.H., Yuen, M.M., Cahn, B.A., Shah, J.T., Ward, A., Kim, J.A., Gilmore, E.J., Falcone, G.J., Petersen, N., Gobeske, K.T., Kaddouh, F., Hwang, D.Y., Schindler, J., Sansing, L., Matouk, C., Rothberg, J., Sze, G., Siner, J., Rosen, M.S., Spudich, S., Kimberly, W.T.. Assessment of Brain Injury Using Portable, Low-Field Magnetic Resonance Imaging at the Bedside of Critically Ill Patients. Jama Neurol 78, 41–47, 2020.
Cooley, C.Z., McDaniel, P.C., Stockmann, J.P., Srinivas, S.A., Cauley, S.F., Śliwiak, M., Sappo, C.R., Vaughn, C.F., Guerin, B., Rosen, M.S., Lev, M.H., Wald, L.L.. A portable scanner for magnetic resonance imaging of the brain. Nat Biomed Eng 5, 229–239, 2020.
D. E. J. Waddington, T. Boele, R. Maschmeyer, Z. Kuncic, and M. S. Rosen, “High-sensitivity in vivo contrast for ultra-low field magnetic resonance imaging using superparamagnetic iron oxide nanoparticles,” Science Advances, vol. 6, no. 29, p. eabb0998, Jul. 2020.
S. Lehmkuhl, M. Suefke, A. Kentner, Y.-F. Yen, B. Blümich, M. S. Rosen, S. Appelt, and T. Theis, “SABRE polarized low field rare-spin spectroscopy,” The Journal of Chemical Physics, vol. 152, no. 18, p. 184202, May 2020.
B. Sveinsson, N. Koonjoo, B. Zhu, T. Witzel, and M. Rosen, “Detection of nanotesla AC magnetic fields using steady-state SIRS and ultra-low field MRI,” J. Neural Eng., Apr. 2020.
O. Perlman, H. Ito, K. Herz, N. Shono, H. Nakashima, M. Zaiss, E. A. Chiocca, O. Cohen, M. S. Rosen, and C. T. Farrar, “AI boosted molecular MRI for apoptosis detection in oncolytic virotherapy,” bioRxiv, vol. 3. Cold Spring Harbor Laboratory, p. 2020.03.05.977793, 06-Mar-2020.
J. G. Skinner, K. Ranta, N. Whiting, A. M. Coffey, P. Nikolaou, M. S. Rosen, E. Y. Chekmenev, P. G. Morris, M. J. Barlow, and B. M. Goodson, “High Xe density, high photon flux, stopped-flow spin-exchange optical pumping: Simulations versus experiments,” Journal of Magnetic Resonance, vol. 312, p. 106686, Mar. 2020.
O. Perlman, K. Herz, M. Zaiss, O. Cohen, M. S. Rosen, and C. T. Farrar, “CEST MR‐Fingerprinting: Practical considerations and insights for acquisition schedule design and improved reconstruction,” Magnetic Resonance in Medicine, vol. 83, no. 2, pp. 462–478, Feb. 2020.
S. J. Devience and M. S. Rosen, “Manipulating Singlet Order by Spin-lock Induced Crossing,” in Long-lived Nuclear Spin Order Theory and Applications, G. Pileio, Ed. Cambridge: Royal Society of Chemistry, 2020, pp. 151–168.
G. C. Bagnall, N. Koonjoo, S. A. Altobelli, M. S. Conradi, E. Fukushima, D. O. Kuethe, J. E. Mullet, H. Neely, W. L. Rooney, K. F. Stupic, B. Weers, B. Zhu, M. S. Rosen, and C. L. S. Morgan, “Low-field magnetic resonance imaging of roots in intact clayey and silty soils,” Geoderma, vol. 370, p. 114356, 2020.
S. Shen, Z. Xu, N. Koonjoo, and M. S. Rosen, “Optimization of a close-fitting volume RF coil for brain imaging at 6.5 mT using linear programming,” Trans. Biomed. Engineering, 2020.
L. A. Colucci, K. M. Corapi, M. Li, X. V. Parada, A. S. Allegretti, H. Y. Lin, D. A. Ausiello, M. S. Rosen, and M. J. Cima, “Fluid assessment in dialysis patients by point-of-care magnetic relaxometry,” Science Translational Medicine, vol. 11, no. 502, p. eaau1749, Jul. 2019.
R. V. Shchepin, J. R. Birchall, N. V. Chukanov, K. V. Kovtunov, I. V. Koptyug, T. Theis, W. S. Warren, J. G. Gelovani, B. M. Goodson, S. Shokouhi, M. S. Rosen, Y.-F. Yen, W. Pham, and E. Y. Chekmenev, “Hyperpolarizing Concentrated Metronidazole 15 NO2 Group over Six Chemical Bonds with More than 15 % Polarization and a 20 Minute Lifetime.,” Chemistry, vol. 25, no. 37, pp. 8829–8836, Jul. 2019.
N. M. Ariyasingha, O. G. Salnikov, K. V. Kovtunov, L. M. Kovtunova, V. I. Bukhtiyarov, B. M. Goodson, M. S. Rosen, I. V. Koptyug, J. G. Gelovani, and E. Y. Chekmenev, “Relaxation Dynamics of Nuclear Long-Lived Spin States in Propane and Propane-d6 Hyperpolarized by Parahydrogen,” J. Phys. Chem. C, p. acs.jpcc.9b01538, Apr. 2019.
O Cohen, S Huang, M T McMahon, M S. Rosen, and C T Farrar, “Rapid and quantitative chemical exchange saturation transfer (CEST) imaging with magnetic resonance fingerprinting (MRF),” Magnetic Resonance in Medicine, vol. 44, pp. 799–15, May 2018.
O. Cohen, B. Zhu, and M. S. Rosen. MR fingerprinting Deep RecOnstruction NEtwork (DRONE). Magn Reson Med. 2018;00:1–10. March 2018
B. Zhu, J. Z. Liu, S. F. Cauley, B. R. Rosen, and M. S. Rosen, “Image reconstruction by domain-transform manifold learning,” Nature, vol. 555, no. 7697, pp. 487 EP ––492, Mar. 2018.
D. E. J. Waddington, M. Sarracanie, N. Salameh, F. Herisson, C. Ayata, and M. S. Rosen, “An Overhauser‐enhanced‐MRI platform for dynamic free radical imaging in vivo,” NMR in Biomedicine, vol. 32, p. e3896, Mar. 2018.
D. E. J. Waddington, M. Sarracanie, H. Zhang, N. Salameh, D. R. Glenn, E. Rej, T. Gaebel, T. Boele, R. L. Walsworth, D. J. Reilly, and M. S. Rosen, “Nanodiamond-enhanced MRI via in situ hyperpolarization,” Nature Communications, vol. 8, pp. 1–8, Apr. 2017.
D. A. Barskiy, A. M. Coffey, P. Nikolaou, D. M. Mikhaylov, B. M. Goodson, R. T. Branca, G. J. Lu, M. G. Shapiro, V.-V. Telkki, V. V. Zhivonitko, I. V. Koptyug, O. G. Salnikov, K. V. Kovtunov, V. I. Bukhtiyarov, M. S. Rosen, M. J. Barlow, S. Safavi, I. P. Hall, L. Schröder, and E. Y. Chekmenev, “NMR Hyperpolarization Techniques of Gases,” Chem. Eur. J., vol. 23, no. 4, pp. 725–751, 2017.
O. Cohen and M. S. Rosen, “Algorithm comparison for schedule optimization in MR fingerprinting,” Magnetic resonance imaging, pp. 1–7, Mar. 2017.
N. Salameh, M. Sarracanie, B. D. Armstrong, M. S. Rosen, and A. Comment, “Overhauser‐enhanced magnetic resonance elastography,” NMR in Biomedicine, pp. 1099–1492, Jan. 2016.
S. J. Devience, R. L. Walsworth, and M. S. Rosen, “Probing scalar coupling differences via long-lived singlet states,” Journal of Magnetic Resonance, vol. 262, no. C, pp. 42–49, Jan. 2016.
Sarracanie M, LaPierre C D, Salameh N, Waddington D E J, Witzel T, and and Rosen MS, Low-Cost High-Performance MRI. Nature Scientific Reports (2015).
Sarracanie M, Armstrong BD, Stockman J, and Rosen MS, High Speed 3D Overhauser-Enhanced MRI Using Combined b-SSFP and Compressed Sensing. Magnetic Resonance in Medicine (2014).
DeVience S, Walsworth RL, and Rosen MS, Preparation of Nuclear Spin Singlet States Using Spin-Lock Induced Crossing. Phys. Rev. Lett. 111:173002 (2013).
Nikolaou P, Coffey AM, Walkup LL, Gust BM, Whiting N, Newton H, Barcus S, Muradyan I, Dabaghyan M, Moroz GD, Rosen MS, Patz S, Barlow MJ, Chekmenev EY, Goodson BM. Near-unity nuclear polarization with an open-source 129Xe hyperpolarizer for NMR and MRI. Proceedings of the National Academy of Sciences. 14 Aug 2013.
DeVience S, Walsworth RL, and Rosen MS, Nuclear spin singlet states as a contrast mechanism for NMR spectroscopy. NMR in Biomedicine (2013).
DeVience S, Walsworth RL, and Rosen MS, Dependence of nuclear spin singlet lifetimes on RF spin-locking power. Journal of Magnetic Resonance 218, 5-10 (2012).
Aptekar JW, Cassidy MC, Johnson AC, Barton RA, Memyoung L, Ogier AC, Vo C, Anahtar MN, Ren Y, Bhatia SN, Ramathan C, Corey DG, Hill AL, Mair RW, Rosen MS, Walsworth RL, and Marcus, CM. Silicon Nanoparticles as Hyperpolarized Magnetic Resonance Imaging Agents. ACS Nano 3, 4003-4008 (2009).
Reference & Dissertations
Colucci, Lina., Quantifying Fluid Overload with Portable Magnetic Resonance Sensors. MIT (2018).
Waddington, David E J., Diamonds on the inside: imaging nanodiamonds with hyperpolarized MRI. The University of Sydney (2018).
Zimmerman Cooley, C., Portable Low-Cost Magnetic Resonance Imaging. MIT (2014).
DeVience, S J., Nuclear Magnetic Resonance with Spin Singlet States and Nitrogen Vacancy Centers in Diamond. Harvard Univeristy (2014).
Stockman, J., New Strategies for Accelerated Spatial Encoding with Quadratic Fields in Magnetic Resonance Imaging. Yale University (2012).
LaPierre, C D, Identification of Optimal Dosing Regimes for Procedures Requiring Esophageal Instrumentation Through Multiobjective Optimization. The University of Utah (2012).
Sarracanie, M., Imagerie quantitative du depot d’aerosols dans les voies aeriennes par resonance magnetique de l’helium-3 hyperpolarise. Universite Paris Sud (2011).
Armstrong, B D., Overhauser Dynamic Nuclear Polarization to Study Hydration Dynamics. University of California Santa Barbara (2010).
Rosen, M S., Laser-polarized 129Xe Magnetic Resonance Spectroscopy and Imaging; the Development of a Method for In Vivo Perfusion Measurement. The University of Michigan (2001).
